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julio 12, 2023

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Plasma and tissue concentrations of clenbuterol (CLB) were determined following oral (p. ) administration of 1. 6 microg/kg twice daily (b. ) for 2 weeks. Horses were administered the last dose on morning of day 15, killed at 0. 25, 24, 48, and 72 h post-administration. General Clenbuterol is used as a bronchodilator for horses and non-lactating cattle. The recommended treatment schedule is 0. 8 m g/kg BW twice daily. The maximum duration of treatment in non-lactating cattle is 10 days. It may be administered by the oral or intravenous routes of administration. Abstract Reasons for performing study: The use of clenbuterol in performance horses necessitates the establishment of appropriate withdrawal times. Objectives: To describe plasma and urine concentrations of clenbuterol following administration of 2 commonly used dosing regimens to racing fit Thoroughbreds. Clenbuterol, along with good stable management that reduces the horse's exposure to dust and to high ammonia concentrations from urine in poorly ventilated stalls, is used to manage chronic obstructive pulmonary disease. Horse owners and handlers sometimes use clenbuterol as a performance-enhancing drug in racehorses. The terminal elimination half-life ranged from 5. 5 hours with a mean of 10. 4 (±4) hours following low dose administration. Urine clenbuterol concentrations were below the LOD between 21 and 28 days in all horses that received the low-dose administration and 5 out of 6 horses receiving the escalating protocol. The initial half-life of serum and urine clenbuterol residues in horses were estimated to be 3. 5 and 8 h; the slower elimination for serum and urine approximately 24 and 48 h, respectively

 

Dosage and Administration Drug side effects are unlikely with clenbuterol, but occasionally include increased heart rate, trembling, excitement, and sweating. For bronchospasm in equines, the recommended dosage via oral route is typically 0. 0008 mg/kg at a concentration of 0. 0725 mg/ml, 2 times a day for 3 days. After a ten-day treatment (0. 8mg/kg q 12 h), the half-life of eliminationfrom plasma is about ten hours and plasma levels are below the pharmacological thresholdwithinthree days. Urinary elimination is prolonged and irregular so that control of clenbuterol usage inracehorses should be based on blood rather than urine levels. Introduction Clenbuterol is an orally active, potent, and selective beta-2 adrenoceptor agonist (causes bronchodilation), used in the treatment of asthma in European countries Kamburoff et al (1977) Tschan et al (1979) Daubert et al (2007) Kamalakkannan et al (2008). PMID: 11106998 Abstract Clenbuterol, a beta2 agonist/antagonist, is the only bronchodilator approved by the US Food and Drug Administration for use in horses. The Association of Racing Commissioners International classifies clenbuterol as a class 3 agent, and, as such, its identification in post-race samples may lead to sanctions. The terminal elimination half-life ranged from 5. 5 hours with a mean of 10. 4 (±4) hours following low dose administration. Urine clenbuterol concentrations were below the LOD between 21 and 28 days in all horses that received the low-dose administration and 5 out of 6 horses receiving the escalating protocol. PMID: 15096103 DOI: 10. X Abstract The pharmacokinetics of clenbuterol (CLB) following a single intravenous (i. ) and oral (p. ) administration twice daily for 7 days were investigated in thoroughbred horses Why did canelo take clenbuterol

 

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